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Ashwagandha Extract Withanolides
Withanolides are a group of naturally occurring steroid lactones, found in Ashwagandha roots. The standardization of Ashwagandha extract is commonly done by using withanolides as the marker compounds.

Botanical Source: Ashwagandha (Withania somnifera)
Extraction Part: Root
Extraction Method: Ethanol extraction
Extraction Solvent: Ethanol or methanol
Detection Method: HPLC
Odor: Odorless
Color: Light yellow to brownish
Appearance: Powder
CAS Number: **********5 (withanolide A)
Molecular Formula: C*8H*8O6
Molecular Weight: **0.*0 g/mol
 
Pharmacological Properties

1. Adaptogenic Properties:
Withanolides have been extensively studied for their adaptogenic properties, which help the body cope with stress. They work by regulating the levels of cortisol, a hormone released in response to stress. Withanolides help to reduce cortisol levels and thereby reduce the negative effects of stress on the body. This makes Ashwagandha extract a popular herbal supplement for managing stress and anxiety.
 
2. Anti-Inflammatory Properties: Withanolides possess potent anti-inflammatory properties that help to reduce inflammation in the body. Studies have shown that withanolides can suppress the activity of pro-inflammatory cytokines, which are responsible for triggering inflammation. This makes Ashwagandha extract an effective natural remedy for reducing joint pain and inflammation.
 
3. Immunomodulatory Properties: Withanolides have been found to possess immunomodulatory properties, meaning they can modulate or regulate the immune system. They have been shown to increase the production of white blood cells, which are responsible for fighting infections and diseases. Withanolides also help to regulate the immune response by suppressing the activity of certain immune cells that can cause autoimmune disorders.
 
4. Antioxidant Properties: Withanolides are potent antioxidants that help to protect the body from oxidative stress. They work by scavenging free radicals, which are unstable molecules that can damage cells and contribute to the development of various diseases. Withanolides also increase the levels of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the body, which help to protect against oxidative damage.
 
5. Neuroprotective Properties: Withanolides have been found to possess neuroprotective properties, meaning they help to protect the brain and nervous system from damage. They have been shown to improve cognitive function, enhance memory and learning, and reduce anxiety and depression. Withanolides also protect against neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
 
6. Anticancer Properties: Withanolides have been found to possess anticancer properties, meaning they can inhibit the growth and spread of cancer cells. Studies have shown that withanolides can induce apoptosis (cell death) in cancer cells, inhibit angiogenesis (the formation of new blood vessels), and prevent metastasis (the spread of cancer cells to other parts of the body).