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Monobasic Calcium Phosphate FCC Food Grade

Monocalcium Phosphate; Calcium Biphosphate; Acid Calcium Phosphate
Ca(H2PO4)2 Formula wt, anhydrous **4.*5
Ca(H2PO4)2·H2O Formula wt, monohydrate **2.*7
CAS: anhydrous [********8]
INS: **1(i) CAS: monohydrate [*********8]

DESCRIPTION 
Calcium Phosphate, Monobasic, occurs as white crystals or granules or as a granular powder. It is anhydrous or contains one molecule of water of hydration, but because of its deliquescent nature, more than the calculated amount of water may be present. It is sparingly soluble in water and is insoluble in alcohol.

Function: Buffer; dough conditioner; firming agent; leavening agent; nutrient; yeast food; sequestrant.

REQUIREMENTS
Labeling: Indicate the state of hydration.
Identification: A. Dissolve **0 mg of sample by warming it in a mixture of 2 mL of 2.7 N hydrochloric acid and 8 mL of water. Add 5 mL of ammonium oxalate TS. A white precipitate forms.

B. Add ammonium molybdate TS to a warm solution of sample in a slight excess of nitric acid. A yellow precipitate of ammonium phosphomolybdate forms.

Assay: Anhydrous: Not less than *6.8% and not more than *8.3% of Ca; Monohydrate: Not less than *5.9% and not more than *7.7% of Ca.
Arsenic: Not more than 3 mg/kg.
Fluoride: Not more than 0.**5%.
Lead: Not more than 2 mg/kg.
Loss on Drying: Monohydrate: Not more than 1%.
Loss on Ignition Anhydrous: Between *4.0% and *5.5%.

Calcium Hydrogen Phosphate BP

Dibasic Calcium Phosphate BP

Calcium Hydrogen Phosphate Dihydrate
CaHPO4,2H2O *- M.wt **2.1 *- cas# ********7

DEFINITION
Content
Dibasic Calcium Phosphate *8.0 per cent to **5.0 per cent.

CHARACTERS
Appearance
White, crystalline powder.
Solubility
Practically insoluble in cold water and in alcohol. It dissolves in dilute hydrochloric  acid and in dilute nitric acid.

IDENTIFICATION

A. Dissolve 0.1 g in a mixture of 5 ml of dilute nitric acid and 5 ml of water. The solution gives reaction of phosphates.
B. 5 mg gives reaction of calcium.
C. It complies with the limits of the assay.

TESTS

Solution S
Dissolve 2.5 g in *0 ml of dilute hydrochloric acid, filter if necessary and add dilute  ammonia until a precipitate is formed. Add just sufficient dilute hydrochloric acid  to dissolve the precipitate and dilute to *0 ml with distilled water.

Carbonates: Shake 0.5 g with 5 ml of carbon dioxide-free water and add 1 ml of hydrochloric  acid. No effervescence is produced.
Chlorides: Maximum **0 ppm.
Dissolve 0.5 g in a mixture of 1 ml of nitric acid and *0 ml of water and dilute to  *0 ml with water. *5 ml of the solution complies with the limit test for chlorides.

Fluorides: Maximum **0 ppm.
Sulphates: Maximum 0.5 per cent.
Arsenic: Maximum *0 ppm.
Barium: To *0 ml of solution S add 0.5 ml of dilute sulphuric acid. After *5 min, any opalescence in the solution is not more intense than that in a mixture of *0 ml of solution S and 0.5 ml of distilled water. 
Iron: Maximum **0 ppm.
Heavy metals: Maximum *0 ppm.
1 ml of 0.1 M sodium edetate is equivalent to *7.*1 mg of CaHPO4,2H2O.

Dibasic Calcium Phosphate USP NF

Dibasic Calcium Phosphate
CaHPO4 **6.*6
Phosphoric acid, calcium salt (1:1).
Calcium phosphate (1:1) [********9].
Dihydrate **2.*9 [********7].

Dibasic Calcium Phosphate is anhydrous or contains two molecules of water of hydration. It contains not less than *8.0 percent and not more than **5.0 percent of anhydrous dibasic calcium phosphate (CaHPO4) or of dibasic calcium phosphate dihydrate (CaHPO4·2H2O).

Labeling— Label it to indicate whether it is anhydrous or the dihydrate.
Identification— A: Dissolve about **0 mg by warming with a mixture of 5 mL of 3 N hydrochloric acid and 5 mL of water, add 2.5 mL of 6 N ammonium hydroxide drop wise, with shaking, and then add 5 mL of ammonium oxalate TS: a white precipitate is formed.

B: To *0 mL of a warm solution (1 in **0) in a slight excess of nitric acid add *0 mL of ammonium molybdate TS: a yellow precipitate of ammonium phosphomolybdate is formed.

Loss on ignition— Ignite it at **0 to **5 to constant weight: anhydrous Dibasic Calcium Phosphate loses between 6.6% and 8.5% of its weight, and the dihydrate form of Dibasic Calcium Phosphate loses between *4.5% and *6.5% of its weight.

Carbonate— Mix 1.0 g with 5 mL of water, and add 2 mL of hydrochloric acid: no effervescence occurs.

Chloride— To 0.*0 g add *0 mL of water and 2 mL of nitric acid, and warm gently, if necessary, until no more dissolves. Dilute to *5 mL, filter, if necessary, and add 1 mL of silver nitrate. TS: the turbidity does not exceed that produced by 1.0 mL of 0.**0 N hydrochloric acid (0.*5%).

Sulfate— Dissolve 1.0 g in the smallest possible amount of 3 N hydrochloric acid, dilute with water to **0 mL, and filter, if necessary. To *0 mL of the filtrate add 1 mL of barium chloride. TS: the turbidity does not exceed that produced by 1.0 mL of 0.**0 N sulfuric acid (0.5%).

Arsenic—The limit is 3 µg per g.

Barium— Heat 0.*0 g with *0 mL of water, and add hydrochloric acid drop wise, stirring after each addition, until no more dissolves. Filter, and to the filtrate add 2 mL of potassium sulfate TS: no turbidity is produced within *0 minutes.

Heavy metals—: the limit is 0.**3%.

Limit of acid-insoluble substances— not more than 0.2% of acid-insoluble substances is found

Calcium Phosphate, Dibasic FCC Food Grade

Dicalcium Phosphate
CaHPO4 Formula wt, anhydrous **6.*6
CaHPO4·2H2O Formula wt, dihydrate **2.*9
INS: **1(ii) CAS: anhydrous [********9]
CAS: dihydrate [********7]

DESCRIPTION
Calcium Phosphate, Dibasic, occurs as a white powder. It is anhydrous or contains two molecules of water of hydration. It is stable in air. It is insoluble in alcohol, is practically insoluble in water, but is readily soluble in dilute hydrochloric and nitric acids.

Function: Leavening agent; dough conditioner; nutrient; yeast food.

REQUIREMENTS
Labeling: Indicate whether it is anhydrous or the dihydrate.
Identification: 

A. Dissolve about **0 mg of sample by warming it with a mixture of 5 mL of 2.7 N hydrochloric acid and 5 mL of water. Add 2.5 mL of 6 N ammonium hydroxide, drop-wise, with shaking, and then add 5 mL of ammonium oxalate TS. A white precipitate forms.

B. Add *0 mL of ammonium molybdate TS to *0 mL of a warm 1:**0 aqueous solution in a slight excess of nitric acid. A yellow precipitate of ammonium phosphomolybdate forms.

Assay Anhydrous or Dihydrate: Not less than *7.0% and not more than **5.0% Dibasic Calcium Phosphate.
Arsenic: Not more than 3 mg/kg.
Fluoride: Not more than 0.**5%.
Lead: Not more than 2 mg/kg.
Loss on Ignition Anhydrous: Between 7.0% and 8.5%; Dihydrate: Between *4.5% and *6.5%.

Tribasic Calcium Phosphate BP

Calcium Phosphate BP
********8

DEFINITION
Calcium phosphate consists of a mixture of calcium phosphates. It contains not less than *5.0 per cent and not more than the equivalent of *0.0 per cent of Ca (Ar *0.*8).

CHARACTERS
A white or almost white powder, practically insoluble in water. It dissolves in dilute hydrochloric acid and in dilute nitric acid.

IDENTIFICATION
A. Dissolve 0.1 g in 5 ml of a *5 per cent V/V solution of nitric acid R. The solution gives reaction (b) of phosphates (2.3.1).
B. It gives reaction (b) of calcium (2.3.1). Filter before adding potassium ferrocyanide solution R.
C. It complies with the limits of the assay.

TESTS
Solution S
Dissolve 2.*0 g in *0 ml of dilute hydrochloric acid. If the solution is not clear, filter  it. Add dilute ammonia drop-wise until a precipitate is formed. Dissolve the precipitate by adding dilute hydrochloric acid and dilute to *0 ml with distilled water.

Chlorides: Dissolve 0.*2 g in a mixture of 1 ml of nitric acid and *0 ml of water and dilute to  **0 ml with water. *5 ml of the solution complies with the limit test for chlorides  (0.*5 per cent).

Fluorides: Not more than *5 ppm of F, determined potentiometrically (2.2.*6, Method I) using a  fluoride-selective indicator electrode and a silver-silver chloride reference electrode.

Sulphates: Dilute 1 ml of solution S to *5 ml with distilled water *5 ml of the solution  complies with the limit test for sulphates (0.5 per cent).

Arsenic: 5 ml of solution S complies with limit test A for arsenic (4 ppm).

Iron: Dilute 0.5 ml of solution S to *0 ml with water R. The solution complies with the limit  test for iron (**0 ppm).

Heavy metals: Dilute *3 ml of solution S to *0 ml with water. *2 ml of the solution complies with limit test A for heavy metals (*0 ppm).

Acid-insoluble matter

Dissolve 5.0 g in a mixture of *0 ml of hydrochloric acid and *0 ml of water.  Filter, wash the residue with water and dry to constant mass at **0°C to **5 °C.  The residue weighs not more than *0 mg (0.2 per cent).

Loss on ignition

Not more than 8.0 per cent, determined on 1.**0 g by ignition at **0 °C for *0 min

Tribasic Calcium Phosphate USP

Tribasic Calcium Phosphate

Ca5(OH)(PO4)3 **2.*1

Calcium hydroxide phosphate (Ca5(OH)(PO4)3).

Calcium hydroxide phosphate (Ca5(OH)(PO4)3) [*********7].

Tribasic Calcium Phosphate consists of a variable mixture of calcium phosphates having the approximate composition *0CaO·3P2O5·H2O. It contains not less than *4.0 percent and not more than *0.0 percent of calcium (Ca).

Identification—

A: To a warm solution in a slight excess of nitric acid add ammonium molybdate TS: a yellow precipitate is formed.

B: It responds to the flame test for Calcium.

Loss on ignition— Ignite it at **0 for *0 minutes: it loses not more than 8.0% of its weight.

Water-soluble substances— Digest 2 g with **0 mL of water on a steam bath for *0 minutes, cool, add sufficient water to restore the original volume, stir well, and filter. Evaporate *0 mL of the filtrate in a tarred porcelain dish on a steam bath to dryness, and dry the residue at **0 to constant weight: the weight of the residue does not exceed 5 mg (0.5%).

Acid-insoluble substances— If an insoluble residue remains in the test for Carbonate, boil the solution, filter, wash the residue well with hot water until the last washing is free from chloride, and ignite the residue to constant weight: the weight of the residue does not exceed 4 mg (0.2%).

Carbonate— Mix 2 g with *0 mL of water, and add 3 N hydrochloric acid, drop wise, to effect solution: no effervescence is produced.

Chloride— Dissolve **0 mg in *5 mL of 2 N nitric acid, and add 1 mL of silver nitrate TS: the turbidity does not exceed that produced by 1.0 mL of 0.**0 N hydrochloric acid (0.*4%).

Sulfate— Dissolve **0 mg in the smallest possible amount of 3 N hydrochloric acid, dilute with water to **0 mL, filter, if necessary, and to *5 mL of the filtrate add 1 mL of barium chloride TS: the turbidity does not exceed that produced by 1.0 mL of 0.**0 N sulfuric acid (0.8%).

Arsenic — The limit is 3 ppm.

Barium— Mix **0 mg with *0 mL of water, heat, add hydrochloric acid drop-wise until solution is effected, and then add 2 drops of the acid in excess. Filter, and add to the filtrate 1 mL of potassium sulfate TS: no turbidity appears within *5 minutes.

Dibasic salt and calcium oxide— Weigh accurately about 1.5 g, and dissolve by warming with *5.0 mL of 1 N hydrochloric acid VS. Cool, and slowly titrate the excess of 1 N hydrochloric acid, while agitating constantly, with 0.1 N sodium hydroxide VS to a pH of 4.0, determined potentiometrically. Not less than *3.0 mL and not more than *4.3 mL of 1 N hydrochloric acid is consumed for each g of salt, calculated on the ignited basis.

Limit of fluoride— [NOTE—Prepare and store all solutions in plastic containers.]: The limit is 0.***5%.

Limit of nitrate— Mix **0 mg with 5 mL of water, and add just sufficient hydrochloric acid to effect solution. Dilute with water to *0 mL, add 0.*0 mL of indigo carmine TS, then add, with stirring, *0 mL of sulfuric acid: the blue color persists for not less than 5 minutes.

Calcium Phosphate, Tribasic FCC Food Grade

Tricalcium Phosphate; Precipitated Calcium Phosphate
Calcium Hydroxyapatite
Ca3(PO4)2 Formula wt **0.*8
Ca5OH(PO4)3 Formula wt **2.*1
Ca*0(OH)2(PO4)6 Formula wt ***4.*1
INS: **1(iii) CAS: [********4]
CAS: [********5
CAS: [*********4]

DESCRIPTION
Calcium Phosphate, Tribasic, occurs as a white powder that is stable in air. It consists of a variable mixture of calcium phosphates. It is insoluble in alcohol and almost insoluble in water, but it dissolves readily in dilute hydrochloric and nitric acids.

Function: Ant caking agent; buffer; nutrient; clouding agent.

REQUIREMENTS
Identification
A. Add ammonium molybdate TS to a warm solution of sample in a slight excess of nitric acid. A yellow precipitate forms.

B. Dissolve about **0 mg of sample by warming it with 5 mL of 2.7 N hydrochloric acid and 5 mL of water; while shaking, add 1 mL of 6 N ammonium hydroxide, drop-wise and then add 5 mL of ammonium oxalate TS. A white precipitate forms.

Assay: Not less than *4.0% and not more than *0.0% of calcium (Ca).
Arsenic: Not more than 3 mg/kg.
Fluoride: Not more than 0.***5%.
Lead: Not more than 2 mg/kg.
Loss on Ignition: Not more than *0.0%