Ziprasidone cas 146939-27-7

الوصف

** is an atypical antipsychotic, belonging to the benzisothiazolylpiperazine class of compounds, whose structure is different from that of other SGAs.In vitro, it has a strong affinity for dopamine D2, D3, *-HT2A, *-HT2C, *-HT1A, *-HT1D and α*-adrenergic receptors; and a moderate affinity for histamine H1 receptors. It has antagonistic effects on dopamine D1, D2, *-HT2A, *-HT1D, and agonistic effects on *-HT1A receptors. It inhibits the reuptake of *-HT and norepinephrine Chemicalbook adenosine in the presynaptic membrane. The mechanism of action is not clear, may be through the combined antagonism of dopamine D2 and *-HT2 and anti-schizophrenia efficacy, its blocking strength is similar to risperidone and haloperidol, than olanzapine, quetiapine and clozapine mean stronger, mainly used for acute or chronic, first-episode or recurrent schizophrenia, schizophrenia, schizophrenia, the negative, positive symptoms of the effect of both. Especially the negative symptoms are more effective. It can reduce positive symptoms such as hallucinations, delusions, abnormal thinking and actions; also improve the negative symptoms such as emotional monotony and reduced volitional behaviour.