Galanthamine Hydrobromide API (substance)

Description

Galanthamine hbr - inhibitor of cholinesterase. Galanthamine hydrobromide is bromhydrate salt of the alkaloid galantaminum, isolated from the galantus voronovi, galantus nivalis) and ungernia victori. Galantamine hydrobromide is strong inhibitor of cholinestherase. Drug potentiates cholinomimetic effect of acetylcholine on cholinoreceptors, facilitates neuromuscular conductance that blocked by antidepolarising myorelaxants; increases a tone of smooth musculature and increases a secretion of digestive glands. The drug easily penetrates across blood-brain barrier and facilitates conductance of impulses in cholinergic synapses of cns. Galantamine hydrobromide is prescribed: For the motor and sensitive disturbances, combined with neuritis, polyneuritis, radiculitis; for residual manifestation, caused by disturbances of brain circulation; for psychogenic impotency and pathology of nervous conductance; at the recovery period after acute poliomyelitis and in cases of children&#**9;s cerebral palsy, galantamine restores the motor activity. Galantamine hydrobromide is not advised in cases of epilepsy, hyperkinesias, bronchial asthma, bradycardia, ulcers of stomach and duodenum. Galanthamine is available in substance and in ampoules of 1,0 ml of 0,*5; 0,5 and 1,0% solutions.