Description
Griffonia Seed extract *-htp
Item: NL***5
Grade: *8%? *9%
CAS: ******9
Botanical origin: Griffonia simplicifolia
Appearance: Off-white powder
Type of extraction: Ethanol/water
Solubility : Good soluble in water
Griffonia is a genus of flowering plants in the legume family,
Fabaceae. It belongs to the subfamily Caesalpinioideae. Griffonia
is known to have a high concentration of *-HTP in its seeds.
*-Hydroxytryptophan (*-HTP), also known as oxitriptan (INN), is a
naturally occurring amino acid and chemical precursor as well as a
metabolic intermediate in the biosynthesis of the neurotransmitters
serotonin and melatonin from tryptophan.
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*-HTP is sold over-the-counter in the United Kingdom, United States
and Canada as a dietary supplement for use as an antidepressant,
appetite suppressant, and sleep aid, and is also marketed in many
European countries for the indication of major depression under
trade names like Cincofarm, Levothym, Levotonine, Oxyfan, Telesol,
Tript-OH, and Triptum.Several double-blind placebo-controlled
clinical trials have demonstrated the effectiveness of *-HTP in the
treatment of depression, though a lack of high quality studies has
been noted. More and larger studies are needed to determine if
*-HTP is truly effective in treating depression.
*-Hydroxytryptophan is decarboxylated to serotonin
(*-hydroxytryptamine or *-HT) by the enzyme aromatic-L-amino-acid
decarboxylase with the help of vitamin B6. This reaction occurs
both in nervous tissue and in the liver. *-HTP crosses the
blood?brain barrier, while *-HT does not. Excess *-HTP, especially
when administered with Vitamin B6, is thought to be metabolized and
excreted.