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الشخص الذي يمكن الاتصال به Cathy
No,111 Changguo Road, Zibo, Shandong
ZM****3
CAS No.: ***********7 (HCl salt)
Chemical Formula: C*3H*5NO.HCl
MW: **7.*2 (HCl salt)
Purity: *8%
Solubility(R.T.: *5°C): DMSO **0mM (HCl salt)
Stability: **0°C,2 years
Human tissue transglutaminase (TGM2) is a calcium-dependent crosslinking enzyme involved in the posttranslational modification of intra- and extracellular proteins and implicated in several neurodegenerative diseases. ZM****3, a Janus kinase inhibitor, and its metabolite ZM*****9 are potent TGM2 inhibitors with IC(*0) of *0 and 5 nM, respectively. ZM****3 also inhibits other kinase (pIC*0 values = 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4, respectively).
