FOB Price
أحصل على آخر سعر|
Minimum Order
Place of Origin:
-
Price for Minimum Order:
-
Minimum Order Quantity:
-
Packaging Detail:
-
Delivery Time:
-
Supplying Ability:
-
Payment Type:
-
الشخص الذي يمكن الاتصال به Cathy
No,111 Changguo Road, Zibo, Shandong
PHT***7
*-dodecyl-N-(1,3,*-thiadiazol**-yl)benzenesulfonamide
M.Wt: **9.*1
Formula: C*0H*1N3O2S2
Solubility: DMSO
Purity: >*8%
Storage: at **0C 2 years
CAS No.: ***********1
PHT***7 is a Novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. It inhibited Akt and PDPK1 signaling and their downstream targets in sensitive but not resistant cells and tumor xenografts. When given orally, PHT***7 inhibited the growth of human tumor xenografts in immunodeficient mice, with up to *0% inhibition in the most sensitive tumors, and showed greater activity than analogues with C4, C6, or C8 alkyl chains. Inhibition of PDPK1 was more closely correlated to antitumor activity than Akt inhibition.