Urea USP BP IP ACS Analytical Reagent FCC Food Grade

Description

Synonyms: Carbamide, Carbamide resin, Isourea, Carbonyl diamide, Carbonyldiamine
CAS Number: ******6, Molecular Weight: *0.1, Chemical Formula: NH2CONH2, EINECS EC Number: ********5

Urea BP
CH4N2O *- *0.1 *- ******6

DEFINITION
Carbamide
Content: *8.5 per cent to **1.5 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or transparent crystals, slightly hygroscopic.
Solubility: Very soluble in water, soluble in alcohol, practically insoluble in methylene chloride.

IDENTIFICATION
First identification A, B.
Second identification A, C, D.
A. Melting point: **2C to **5C.
B. Infrared absorption spectrophotometry.
C. Dissolve 0.1 g in 1 ml of water. Add 1 ml of nitric acid. A white, crystalline precipitate is formed.
D. Heat 0.5 g in a test tube until it liquefies and the liquid becomes turbid. Cool, dissolve in a mixture of 1 ml of dilute sodium hydroxide solution and *0 ml of water and add 0.*5 ml of copper sulphate solution. A reddish-violet colour is produced.

TESTS
Solution S: Dissolve *0.0 g in water and dilute to *0 ml with the same solvent.
Appearance of solution: The solution is clear and colourless.
To 2.5 ml of solution S add 7.5 ml of water.
Alkalinity: To 2.5 ml of solution S add 7.5 ml of water, 0.1 ml of methyl red solution and 0.4 ml of 0.*1 M hydrochloric acid . The solution is red to orange.
Biuret: Maximum 0.1 per cent.
Ammonium: Maximum **0 ppm, determined on 0.1 ml of solution S.
Heavy metals: Maximum *0 ppm.
Loss on drying: Maximum 1.0 per cent, determined on 1.**0 g by drying in an oven at **5C for 1h.
Sulphated ash: Maximum 0.1 per cent, determined on 1.0 g.

Urea USP
CH4N2O *0.*6
Carbamide.

Urea contains not less than *9.0 percent and not more than **0.5 percent of CH4N2O.

Labeling— Where it is intended for use in preparing injectable dosage forms, the label states that it is sterile or must be subjected to further processing during the preparation of injectable dosage forms.
Identification—
A: Heat about **0 mg in a test tube: it liquefies, and ammonia is evolved. Continue the heating until the liquid becomes turbid, then cool. Dissolve the fused mass in a mixture of *0 mL of water and 1 mL of sodium hydroxide solution (1 in *0), and add 1 drop of cupric sulfate TS: the solution acquires a reddish-violet color.
B: Dissolve **0 mg in 1 mL of water, and add 1 mL of nitric acid: a white crystalline precipitate of urea nitrate is formed.
Melting range: between **2 and **5.
Residue on ignition: not more than 0.1%.
Alcohol-insoluble matter—0.*4%.
Chloride— 0.**7%.
Sulfate— 0.**0%.
Heavy metals— the limit is 0.**2%.
Other requirements— Where the label states that Urea is sterile, it meets the requirements for Sterility Tests *1 and for Bacterial endotoxins under
Urea for Injection:. Where the label states that Urea must be subjected to further processing during the preparation of injectable dosage forms, it meets the requirements for Bacterial endotoxins under Urea for Injection.

Urea FCC
Carbamide
CH4N2O Formula wt *0.*6
CAS: [******6]

DESCRIPTION
Urea occurs as a colorless to white, prismatic, crystalline powder or as small, white pellets. It is commonly produced from CO2 by ammonolysis or from cyanamide by hydrolysis. It is freely soluble in water and in boiling alcohol, but practically insoluble in chloroform and in ether. It melts at a range of **2° to **5°.
Function Fermentation aid.

REQUIREMENTS
Identification:
A. Heat about **0 mg of sample in a test tube until it liquefies. Ammonia vapor is produced. Continue heating until the liquid becomes turbid, and then cool. Dissolve the fused mass in a 1:*0 sodium hydroxide solution:water mixture. Add 1 drop of cupric sulfate TS. A red-violet colored solution develops.
B. Dissolve **0 mg of sample in 1 mL of water, and add 1 mL of nitric acid. A white precipitate of urea nitrate forms.
Assay: Not less than *9.0% and not more than **0.5% of CH4N2O.
Alcohol-Insoluble Matter: Not more than 0.*4%.
Chloride: Not more than 0.**7%.
Lead: Not more than 5 mg/kg.
Loss on Drying: Not more than 1.0%.
Residue on Ignition: Not more than 0.1%.
Sulfate: Not more than 0.*1%.

Urea ACS
NH2CONH2
Formula Wt *0.*6
CAS Number ******6

REQUIREMENTS

MAXIMUM ALLOWABLE